The effect of developmental variation on expression QTLs in a multi parental Caenorhabditis elegans population.

ABSTRACT: Regulation of gene expression plays a crucial role in developmental processes and adaptation to changing environments. expression quantitative trait locus (eQTL) mapping is a technique used to study the genetic regulation of gene expression using the transcriptomes of recombinant inbred lines (RILs). Typically, the age of the inbred lines at the time of RNA sampling is carefully controlled. This is necessary because the developmental process causes changes in gene expression, complicating the interpretation of eQTL mapping experiments. However, due to genetics and variation in ambient micro-environments, organisms can differ in their "developmental age," even if they are of the same chronological age. As a result, eQTL patterns are affected by developmental variation in gene expression. Th

SUBMITTER: van Eijnatten AL 

PROVIDER: S-EPMC10849341 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature