Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients.

ABSTRACT: Immune checkpoint blockade (ICB) therapies have emerged as a promising avenue for the treatment of various cancers. Despite their success, the efficacy of these treatments is variable across patients and cancer types. Numerous single-cell RNA-sequencing (scRNA-seq) studies have been conducted to unravel cell-specific responses to ICB treatment. However, these studies are limited in their sample sizes and require advanced coding skills for exploration. Here, we have compiled eight scRNA-seq datasets from nine cancer types, encompassing 174 patients, and 90,270 cancer cells. This compilation forms a unique resource tailored for investigating how cancer cells respond to ICB treatment across cancer types. We meticulously curated, quality-checked, pre-processed, and analyzed the data, ensuring

SUBMITTER: Gondal MN 

PROVIDER: S-EPMC10849474 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature