Gene expression tradeoffs determine bacterial survival and adaptation to antibiotic stress.

ABSTRACT: To optimize their fitness, cells face the crucial task of efficiently responding to various stresses. This necessitates striking a balance between conserving resources for survival and allocating resources for growth and division. The fundamental principles governing these tradeoffs is an outstanding challenge in the physics of living systems. In this study, we introduce a coarse-grained theoretical framework for bacterial physiology that establishes a connection between the physiological state of cells and their survival outcomes in dynamic environments, particularly in the context of antibiotic exposure. Predicting bacterial survival responses to varying antibiotic doses proves challenging due to the profound influence of the physiological state on critical parameters, such as the Minimu

SUBMITTER: Kratz JC 

PROVIDER: S-EPMC10849509 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature