Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development.

ABSTRACT: Mammalian behavior and physiology undergo dramatic changes in early life. Young animals rely on conspecifics to meet their homeostatic needs, until weaning and puberty initiate nutritional independence and sex-specific social interactions, respectively. How neuronal populations regulating homeostatic functions and social behaviors develop and mature during these transitions remains unclear. We used paired transcriptomic and chromatin accessibility profiling to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, where cell types with key roles in physiological and behavioral control have been identified^1-6. These data reveal a remarkable diversity of developmental trajectories shaped by the sex of the animal, and the location and be

SUBMITTER: Kaplan HS 

PROVIDER: S-EPMC10849564 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature