Propofol Disrupts the Functional Core-Matrix Architecture of the Thalamus in Humans.

ABSTRACT: Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either the thalamus as a whole or focused on specific subregions, overlooking the distinct neuronal subtypes like core and matrix cells. We conducted a study of heathy volunteers and functional magnetic resonance imaging during conscious baseline, deep sedation, and recovery. We advanced the functional gradient mapping technique to delineate the functional geometry of thalamocortical circuits, within a framework of the unimodal-transmodal functional axis of the cortex. We observed a significant shift in this geometry during unconsciousness, marked by the dominance of unimodal over transmodal geometry. Thi

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10849566 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature