Diagnostically distinct resting state fMRI energy distributions: A subject-specific maximum entropy modeling study.

ABSTRACT:

Objective

Existing neuroimaging studies of psychotic and mood disorders have reported brain activation differences (first-order properties) and altered pairwise correlation-based functional connectivity (second-order properties). However, both approaches have certain limitations that can be overcome by integrating them in a pairwise maximum entropy model (MEM) that better represents a comprehensive picture of fMRI signal patterns and provides a system-wide summary measure called energy. This study examines the applicability of individual-level MEM for psychiatry and identifies image-derived model coefficients related to model parameters.

Method

MEMs are fit to resting state fMRI data from each individual with schizophrenia/schizoaffective disorder, bipolar disorder, and majo

SUBMITTER: Theis N 

PROVIDER: S-EPMC10849576 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature