A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1.

ABSTRACT: The heart is a highly plastic organ that responds to diverse stimuli to modify form and function. The molecular mechanisms of adaptive physiological cardiac hypertrophy are well-established; however, the regulation of hypertrophy regression is poorly understood. To identify molecular features of regression, we studied Burmese pythons which experience reversible cardiac hypertrophy following large, infrequent meals. Using multi-omics screens followed by targeted analyses, we found forkhead box protein O1 (FoxO1) transcription factor signaling, and downstream autophagy activity, were downregulated during hypertrophy, but re-activated with regression. To determine whether these events were mechanistically related to regression, we established an in vitro platform of cardiomyocyte hyper

SUBMITTER: Martin TG 

PROVIDER: S-EPMC10849654 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature