Mitochondrial Transplantation promotes protective effector and memory CD4⁺ T cell response during Mycobacterium tuberculosis infection and diminishes exhaustion and senescence in elderly CD4⁺ T cells.

ABSTRACT: Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (M.tb), remains a significant health concern worldwide, especially in populations with weakened or compromised immune systems, such as the elderly. Proper adaptive immune function, particularly a CD4⁺ T cell response, is central to host immunity against M.tb. Chronic infections, such as M.tb, as well as aging promote T cell exhaustion and senescence, which can impair immune control and promote progression to TB disease. Mitochondrial dysfunction contributes to T cell dysfunction, both in aging and chronic infections and diseases. Mitochondrial perturbations can disrupt cellular metabolism, enhance oxidative stress, and impair T-cell signaling and effector functions. This study exami

SUBMITTER: Headley CA 

PROVIDER: S-EPMC10849707 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature