Control of Munc13-1 Activity by Autoinhibitory Interactions Involving the Variable N-terminal Region.

ABSTRACT: Regulation of neurotransmitter release during presynaptic plasticity underlies varied forms of information processing in the brain. Munc13s play essential roles in release via their conserved C-terminal region, which contains a MUN domain involved SNARE complex assembly, and control multiple presynaptic plasticity processes. Munc13s also have a variable N-terminal region, which in Munc13-1 includes a calmodulin binding (CaMb) domain involved in short-term plasticity and a C₂A domain that forms an inhibitory homodimer. The C₂A domain is activated by forming a heterodimer with the zinc-finger domain of αRIMs, providing a link to αRIM-dependent short- and long-term plasticity. However, it is unknown how the functions of the N- and C-terminal regions are integrated, in pa

SUBMITTER: Xu J 

PROVIDER: S-EPMC10849727 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature