M6A-dependent circular RNA formation mediates tau-induced neurotoxicity.

ABSTRACT: Circular RNAs (circRNAs), covalently closed RNA molecules that form due to back-splicing of RNA transcripts, have recently been implicated in Alzheimer's disease and related tauopathies. circRNAs are regulated by N⁶-methyladenosine (m⁶A) RNA methylation, can serve as "sponges" for proteins and RNAs, and can be translated into protein via a cap-independent mechanism. Mechanisms underlying circRNA dysregulation in tauopathies and causal relationships between circRNA and neurodegeneration are currently unknown. In the current study, we aimed to determine whether pathogenic forms of tau drive circRNA dysregulation and whether such dysregulation causally mediates neurodegeneration. We identify circRNAs that are differentially expressed in the brain of a Drosophila m

SUBMITTER: Atrian F 

PROVIDER: S-EPMC10849734 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature