Regional specialization manifests in the reliability of neural population codes.

ABSTRACT: The brain has the remarkable ability to learn and guide the performance of complex tasks. Decades of lesion studies suggest that different brain regions perform specialized functions in support of complex behaviors^1-3. Yet recent large-scale studies of neural activity reveal similar patterns of activity and encoding distributed widely throughout the brain^4-6. How these distributed patterns of activity and encoding are compatible with regional specialization of brain function remains unclear. Two frontal brain regions, the dorsal medial prefrontal cortex (dmPFC) and orbitofrontal cortex (OFC), are a paradigm of this conundrum. In the setting complex behaviors, the dmPFC is necessary for choosing optimal actions^2,7,8, whereas the OFC is necessary for waiting

SUBMITTER: Guidera JA 

PROVIDER: S-EPMC10849741 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature