Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways.

ABSTRACT: Current treatments for neurodegenerative diseases and neural injuries face major challenges, primarily due to the diminished regenerative capacity of neurons in the mammalian CNS as they mature. Here, we investigated the role of Ezh2, a histone methyltransferase, in regulating mammalian axon regeneration. We found that Ezh2 declined in the mouse nervous system during maturation but was upregulated in adult dorsal root ganglion neurons following peripheral nerve injury to facilitate spontaneous axon regeneration. In addition, overexpression of Ezh2 in retinal ganglion cells in the CNS promoted optic nerve regeneration via both histone methylation-dependent and -independent mechanisms. Further investigation revealed that Ezh2 fostered axon regeneration by orchestrating the transcriptional si

SUBMITTER: Wang XW 

PROVIDER: S-EPMC10849760 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature