Apoptotic vesicles derived from human red blood cells promote bone regeneration via carbonic anhydrase 1.

ABSTRACT: Apoptotic vesicles (apoVs) are nanoscale vesicles derived from billions of apoptotic cells involved in the maintenance of the human body's homeostasis. Previous researches have shown that some apoVs, such as those derived from mesenchymal stem cells, contribute to bone formation. However, those apoVs cannot be extracted from patients in large quantities, and cell expansion is needed before apoV isolation, which limits their clinical translation. Mature RBCs, which have no nuclei or genetic material, are easy to obtain, showing high biological safety as a source of extracellular vesicles (EVs). Previous studies have demonstrated that RBC-derived EVs have multiple biological functions, but it is unknown whether RBCs produce apoVs and what effect these apoVs have on bone regeneration. In this

SUBMITTER: Shao Y 

PROVIDER: S-EPMC10849785 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature