Magnetically guided surgery after primary systemic therapy for breast cancer: implications for enhanced axillary mapping.

ABSTRACT:

Background

Superparamagnetic iron nanoparticles perform comparably to radioisotope ± blue dye for sentinel lymph node detection in breast cancer, even when injected up to 8 weeks before surgery. Using superparamagnetic iron nanoparticles for sentinel lymph node detection after primary systemic therapy, and the maximum time frame of superparamagnetic iron nanoparticle administration have not been investigated.

Methods

This cohort study included cN0/1-to-ycN0 patients undergoing sentinel lymph node detection or targeted axillary dissection. All patients received superparamagnetic iron nanoparticles either before primary systemic therapy or before surgery, and radioisotope on the day of surgery.

Results

For 113 patients analysed, superparamagnetic iron nanoparticles were

SUBMITTER: Pantiora E 

PROVIDER: S-EPMC10849829 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature