Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma.

ABSTRACT: Although chemotherapy using CHOP-based protocol induces remission in most cases of canine multicentric high-grade B-cell lymphoma (mhBCL), some cases develop early relapse during the first induction protocol. In this study, we examined the gene expression profiles of canine mhBCL before chemotherapy and investigated their associations with early relapse during the first whole CHOP-based protocol. Twenty-five cases of mhBCL treated with CHOP-based protocol as first induction chemotherapy were included in this study. Sixteen cases completed the first whole CHOP-based protocol without relapse (S-group), and nine developed relapse during the chemotherapy (R-group). RNA-seq was performed on samples from neoplastic lymph nodes. Differentially expressed genes (DEGs) were extracted by the comparis

SUBMITTER: Toyoda H 

PROVIDER: S-EPMC10849849 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature