Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques.

ABSTRACT: A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron subvariants^1,2, although they still provide protection against severe disease. Enhanced mucosal immunity may be required to block infection and onward transmission. Intranasal administration of current vaccines has proven inconsistent^3-7, suggesting that alternative immunization strategies may be required. Here we show that intratracheal boosting with a bivalent Ad26-based SARS-CoV-2 vaccine results in substantial induction of mucosal humoral and cellular immunity and near-complete protection against SARS-CoV-2 BQ.1.1 challenge. A total of 40 previously immunized rhesus macaques were boosted with a bivalent Ad26 vaccine by the intramuscular, intra

SUBMITTER: McMahan K 

PROVIDER: S-EPMC10849944 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature