Latent neural population dynamics underlying breathing, opioid-induced respiratory depression and gasping.

ABSTRACT: Breathing is vital and must be concurrently robust and flexible. This rhythmic behavior is generated and maintained within a rostrocaudally aligned set of medullary nuclei called the ventral respiratory column (VRC). The rhythmic properties of individual VRC nuclei are well known, yet technical challenges have limited the interrogation of the entire VRC population simultaneously. Here we characterize over 15,000 medullary units using high-density electrophysiology, opto-tagging and histological reconstruction. Population dynamics analysis reveals consistent rotational trajectories through a low-dimensional neural manifold. These rotations are robust and maintained even during opioid-induced respiratory depression. During severe hypoxia-induced gasping, the low-dimensional dynamics of the V

SUBMITTER: Bush NE 

PROVIDER: S-EPMC10849970 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature