Modelling post-implantation human development to yolk sac blood emergence.

ABSTRACT: Implantation of the human embryo begins a critical developmental stage that comprises profound events including axis formation, gastrulation and the emergence of haematopoietic system^1,2. Our mechanistic knowledge of this window of human life remains limited due to restricted access to in vivo samples for both technical and ethical reasons^3-5. Stem cell models of human embryo have emerged to help unlock the mysteries of this stage^6-16. Here we present a genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis that captures the reciprocal codevelopment of embryonic tissue and the extra-embryonic endoderm and mesoderm niche with early haematopoiesis. This model is produced from induced pluripotent stem cells and sh

SUBMITTER: Hislop J 

PROVIDER: S-EPMC10849971 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature