BEYOND 2 years: durability of metabolic benefits by simplification of complex insulin regimens in type 2 diabetes.

ABSTRACT:

Purpose

To assess the magnitude and durability of the metabolic benefits by simplification of complex insulin treatments in patients with type 2 diabetes inadequately controlled by a full basal-bolus insulin regimen. Herein we report the results of the scheduled 2-year extension of the BEYOND trial.

Methods

Originally, 305 participants with inadequate glycemic control (HbA1c > 7.5%) were randomly assigned to intensification of basal-bolus insulin regimen (n = 101), to a fixed-ratio combination (basal insulin + GLP-1RA, n = 102), or to an association of basal insulin plus an SGLT-2 inhibitor (gliflo-combo, n = 102). The primary efficacy outcome was change from baseline in HbA1c at 24 months assessed by an intention-to-treat analysis. A per-protocol analysis was also performed

SUBMITTER: Giugliano D 

PROVIDER: S-EPMC10850008 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature