The safety and immunogenicity of vaccines administered to pregnant women living with HIV: a systematic review and meta-analysis.

ABSTRACT:

Background

Human Immunodeficiency Virus (HIV)-exposed uninfected (HEU) infants have a higher burden of infectious diseases related morbidity and mortality compared with HIV-unexposed uninfected (HUU). Immunization of pregnant women living with HIV (PWLWH) could reduce the severity and burden of infectious diseases for HEU in early infancy.

Methods

We conducted a systematic review of safety and immunogenicity of vaccines administered to PWLWH and meta-analyses to test the overall effect of immunogenicity comparing pregnant women without HIV (PWWH) to PWLWH. We searched MEDLINE, Embase, Web of Science, Virtual Health Library and Cochrane databases in accordance with PRISMA guidelines for randomized controlled trials and observational studies. Review articles, case series, conf

SUBMITTER: Nakabembe E 

PROVIDER: S-EPMC10850112 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature