Thyroid transcription factor-1 expression in lung neuroendocrine tumours: a gender-related biomarker?

ABSTRACT:

Purpose

Thyroid transcription factor-1 (TTF-1) assessed by immunohistochemistry (IHC) is a specific biomarker for lung adenocarcinoma, and is commonly used to confirm the pulmonary origin of neuroendocrine tumours (NET). The majority of the available data suggest that TTF-1 is favourable prognostic biomarker for lung adenocarcinomas, whereas its role is more conflicting for lung NET. The main aim of this multicenter retrospective study was to investigate the potentially relevant associations between TTF-1 biomarker and clinical and pathological features of the study population, as well as determine TTF-1 prognostic effect on the clinical outcome of the patients.

Methods

A multicentre retrospective study was conducted on 155 surgically-removed lung NET, with available IHC TTF

SUBMITTER: La Salvia A 

PROVIDER: S-EPMC10850191 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature