Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis.

ABSTRACT:

Background

There is still controversy regarding the relationship between hypothyroidism and rheumatoid arthritis (RA), and there has been a dearth of studies on this association. The purpose of our study was to explore the shared genetic architecture between hypothyroidism and RA.

Methods

Using public genome-wide association studies summary statistics of hypothyroidism and RA, we explored shared genetics between hypothyroidism and RA using linkage disequilibrium score regression, ρ-HESS, Pleiotropic analysis under a composite null hypothesis (PLACO), colocalization analysis, Multi-Trait Analysis of GWAS (MTAG), and transcriptome-wide association study (TWAS), and investigated causal associations using Mendelian randomization (MR).

Results

We found a positive genetic a

SUBMITTER: Peng Z 

PROVIDER: S-EPMC10850220 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature