Mononeuritis multiplex following immune checkpoint inhibitors in malignant pleural mesothelioma.

ABSTRACT:

Introduction

Mononeuritis multiplex is frequently related to vasculitic neuropathy and has been reported only sporadically as an adverse event of immune checkpoint inhibitors.

Methods

Case series of three patients with mononeuritis multiplex-all with mesothelioma-identified in the databases of two French clinical networks (French Reference Center for Paraneoplastic Neurological Syndromes, Lyon; OncoNeuroTox, Paris; January 2015-October 2022) set up to collect and investigate n-irAEs on a nationwide level.

Results

Three patients (male; median age 86 years; range 72-88 years) had pleural mesothelioma and received 10, 4, and 6 cycles, respectively, of first-line nivolumab plus ipilimumab combined therapy. In patient 1, the neurological symptoms involved the median nerves

SUBMITTER: Farina A 

PROVIDER: S-EPMC10850347 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature