Causal relationship between gut microbiota and myasthenia gravis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have provided cumulative data linking gut microbiota to myasthenia gravis (MG). However, the causal link between the two remains unexplored. Hence, the current study was performed to explore the causal link between them.

Methods

Mendelian randomization (MR) analysis was conducted using the summary statistics of 211 gut microbiota taxa and the largest genome-wide association studies (GWAS) for MG currently available. The inverse variance-weighted (IVW), MR-Egger, weighted median, and weighted mode methods were employed to ascertain the causal influence. Sensitivity studies utilizing several methodologies were then used to assess the robustness of the findings. Lastly, to evaluate reverse causality, a reverse MR analysis was performed.

SUBMITTER: Mi C 

PROVIDER: S-EPMC10850378 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature