The prognostic significance and clinical relevance of stem cell characteristic in bladder cancer.

ABSTRACT:

Background

Bladder cancer (BLCA) is a common malignant tumor of urinary system and prognostic biomarkers are needed for better clinical decision-making and patient management. Cancer stem cells (CSCs) are involved in carcinogenesis, development, metastasis and recurrence of BLCA. This study explored the prognostic and predictive value of CSCs-related genes and laid the groundwork for precision treatment development in BLCA.

Methods

The mRNA data and corresponding clinical information obtained from TCGA-BLCA cohort was used to discover biomarkers and develop CSCs-related prognostic model, which was further validated in GSE32548 and GSE32894 datasets. In addition, the association between CSCs-related risk score and therapeutic efficacy was analyzed to explore the potential pre

SUBMITTER: Chen X 

PROVIDER: S-EPMC10850424 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature