Proteomic insights into the pathophysiology of periodic limb movements and restless legs syndrome.

ABSTRACT:

Objectives

We used a high-throughput assay of 5000 plasma proteins to identify biomarkers associated with periodic limb movements (PLM) and restless legs syndrome (RLS) in adults.

Methods

Participants (n = 1410) of the Stanford Technology Analytics and Genomics in Sleep (STAGES) study had blood collected, completed a sleep questionnaire, and underwent overnight polysomnography with the scoring of PLMs. An aptamer-based array (SomaScan) was used to quantify 5000 proteins in plasma. A second cohort (n = 697) that had serum assayed using a previous iteration of SomaScan (1300 proteins) was used for replication and in a combined analysis (n = 2107). A 5% false discovery rate was used to assess significance.

Results

Multivariate analyses in STAGES identified 68 proteins as

SUBMITTER: Cederberg KLJ 

PROVIDER: S-EPMC10850434 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature