CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.

ABSTRACT:

Background

Ovochymase 2 (Ovch2) is an epididymis-specific gene that is required for male fertility. While a multitude of reproductive tract-specific genes required for male fertility have been identified, OVCH2 is thus far the first protein required for male fertility that contains Complement C1r/C1s, Uegf, Bmp1 (CUB) domains located in tandem in the C-terminus of the protein. Identifying the functional significance of this unique domain has implications in better understanding fertility and infertility and as a potential contraceptive target.

Objective

The goals of these studies were to understand the influence and requirement of OVCH2 CUB domains in the localization and functional requirement of OVCH2 in sperm maturation and function.

Materials and methods

To this e

SUBMITTER: Kent K 

PROVIDER: S-EPMC10850435 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature