The human middle ear in motion: 3D visualization and quantification using dynamic synchrotron-based X-ray imaging.

ABSTRACT: The characterization of the vibrations of the middle ear ossicles during sound transmission is a focal point in clinical research. However, the small size of the structures, their micrometer-scale movement, and the deep-seated position of the middle ear within the temporal bone make these types of measurements extremely challenging. In this work, dynamic synchrotron-based X-ray phase-contrast microtomography is used on acoustically stimulated intact human ears, allowing for the three-dimensional visualization of entire human eardrums and ossicular chains in motion. A post-gating algorithm is used to temporally resolve the fast micromotions at 128 Hz, coupled with a high-throughput pipeline to process the large tomographic datasets. Seven ex-vivo fresh-frozen human temporal bones in healthy

SUBMITTER: Schmeltz M 

PROVIDER: S-EPMC10850498 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature