Antiviral fibrils of self-assembled peptides with tunable compositions.

ABSTRACT: The lasting threat of viral pandemics necessitates the development of tailorable first-response antivirals with specific but adaptive architectures for treatment of novel viral infections. Here, such an antiviral platform has been developed based on a mixture of hetero-peptides self-assembled into functionalized β-sheets capable of specific multivalent binding to viral protein complexes. One domain of each hetero-peptide is designed to specifically bind to certain viral proteins, while another domain self-assembles into fibrils with epitope binding characteristics determined by the types of peptides and their molar fractions. The self-assembled fibrils maintain enhanced binding to viral protein complexes and retain high resilience to viral mutations. This method is experimentally and compu

SUBMITTER: Dodd-O J 

PROVIDER: S-EPMC10850501 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature