Gut microbiota, circulating metabolites, and gallstone disease: a Mendelian randomization study.

ABSTRACT:

Background

The link between Gut microbiota (GM) and Gallstone disease (GSD) is well established, but it is not clear whether there is a causal relationship between the two associations.

Methods

We conducted bidirectional Mendelian randomization (MR) analyses, leveraging aggregated data from the Genome-Wide Association Study (GWAS) of GM and Circulating Metabolites. Our primary objective was to investigate the causal interplay between intestinal flora and GSD. Additionally, we performed mediational analyses, two-step MR, and multivariate MR to uncover the potential mediating effect of circulating metabolites in this relationship.

Result

Our study has revealed a causal relationship between GSD and six distinct bacterial groups. Genetically predicted Class Bacilli (Odds

SUBMITTER: Hu X 

PROVIDER: S-EPMC10850572 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature