Growth differentiation factor-15 in patients with or at risk of heart failure but before first hospitalisation.

ABSTRACT:

Objective

Identification of patients at risk of adverse outcome from heart failure (HF) at an early stage is a priority. Growth differentiation factor (GDF)-15 has emerged as a potentially useful biomarker. This study sought to identify determinants of circulating GDF-15 and evaluate its prognostic value, in patients at risk of HF or with HF but before first hospitalisation.

Methods

Prospective, longitudinal cohort study of 2166 consecutive patients in stage A-C HF undergoing cardiovascular magnetic resonance and measurement of GDF-15. Multivariable linear regression investigated determinants of GDF-15. Cox proportional hazards modelling, Net Reclassification Improvement and decision curve analysis examined its incremental prognostic value. Primary outcome was a composite of

SUBMITTER: Bradley J 

PROVIDER: S-EPMC10850645 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature