Antimicrobial susceptibility profile of <i>Neisseria gonorrhoeae</i> from patients attending a medical laboratory, Institut Pasteur de Madagascar between 2014 and 2020: phenotypical and genomic characterisation in a subset of <i>Neisseria gonorrhoeae</i> isolates.

ABSTRACT:

Objectives

Antimicrobial-resistant Neisseria gonorrhoeae (NG) is a concern. Little is known about antimicrobial susceptibility profiles and associated genetic resistance mechanisms of NG in Madagascar. We report susceptibility data of NG isolates obtained by the medical laboratory (CBC) of the Institut Pasteur de Madagascar, Antananarivo, Madagascar, during 2014-2020. We present antimicrobial resistance mechanisms data and phenotype profiles of a subset of isolates.

Methods

We retrieved retrospective data (N=395) from patients with NG isolated during 2014-2020 by the CBC. We retested 46 viable isolates including 6 found ceftriaxone and 2 azithromycin resistant, as well as 33 isolated from 2020. We determined minimal inhibitory concentrations for ceftriaxone, ciproflox

SUBMITTER: Rafetrarivony LF 

PROVIDER: S-EPMC10850657 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature