Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function.

ABSTRACT:

Background

There is growing evidence of a strong correlation between pain sensitivity and cognitive function under both physiological and pathological conditions. However, the detailed mechanisms remain largely unknown. In the current study, we sought to explore candidate genes and common molecular mechanisms underlying pain sensitivity and cognitive function with a transcriptome-wide association study using recombinant inbred mice from the BXD family.

Methods

The pain sensitivity determined by Hargreaves' paw withdrawal test and cognition-related phenotypes were systematically analyzed in 60 strains of BXD mice and correlated with hippocampus transcriptomes, followed by quantitative trait locus (QTL) mapping and systems genetics analysis.

Results

The pain sensitivity

SUBMITTER: Xu F 

PROVIDER: S-EPMC10850811 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature