Wnt/β-catenin Signaling Controls Maxillofacial Hyperostosis.

ABSTRACT: The roles of Wnt/β-catenin signaling in regulating the morphology and microstructure of craniomaxillofacial (CMF) bones was explored using mice carrying a constitutively active form of β-catenin in activating Dmp1-expressing cells (e.g., daβcat^Ot mice). By postnatal day 24, daβcat^Ot mice exhibited midfacial truncations coupled with maxillary and mandibular hyperostosis that progressively worsened with age. Mechanistic insights into the basis for the hyperostotic facial phenotype were gained through molecular and cellular analyses, which revealed that constitutively activated β-catenin in Dmp1-expressing cells resulted in an increase in osteoblast number and an increased rate of mineral apposition. An increase in osteoblasts was accompanied by an increase in osteocytes

SUBMITTER: Chen J 

PROVIDER: S-EPMC10850863 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature