Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy.

ABSTRACT:

Introduction

IgA nephropathy's (IgAN's) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence. Our study aimed to delineate this relationship through a systematic review.

Methods

We adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines and conducted a systematic review, utilizing databases like MEDLINE (PubMed), Embase, Scopus, and Cochrane from January 2016 (year of updated MEST-C classification) to January 2023. We specifically selected studies that employed established methods to evaluate complement activation and the MEST-C classification.

Results

A total of 34 studies with 10,082 patients were included. Among these, 7 studies focused on the pedi

SUBMITTER: Stefan G 

PROVIDER: S-EPMC10851005 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature