Experimental evolution of hybrid populations to identify Dobzhansky-Muller incompatibility loci.

ABSTRACT: Epistatic interactions between loci that reduce fitness in interspecies hybrids, Dobzhansky-Muller incompatibilities (DMIs), contribute genetically to the inviability and infertility within hybrid populations. It remains a challenge, however, to identify the loci that contribute to DMIs as causes of reproductive isolation between species. Here, we assess through forward simulation the power of evolve-and-resequence (E&R) experimental evolution of hybrid populations to map DMI loci. We document conditions under which such a mapping strategy may be most feasible and demonstrate how mapping power is sensitive to biologically relevant parameters such as one-way versus two-way incompatibility type, selection strength, recombination rate, and dominance interactions. We also assess the influence

SUBMITTER: Szabo N 

PROVIDER: S-EPMC10851027 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature