Clinicopathologic Features of Antibrush Border Antibody Disease.

ABSTRACT:

Introduction

Antibrush border antibody disease (ABBA) is an autoimmune tubulointerstitial kidney disease that primarily affects older individuals and results in progressive kidney failure. It is rare with only 20 reported cases. Here, we describe a case series to further define the clinicopathologic spectrum and natural history, and to inform management.

Methods

We identified 67 patients with ABBA who underwent kidney biopsy, including 65 native and 2 transplants. Demographics, clinical findings, and laboratory data were obtained. Histopathologic data included light microscopy, immunofluorescence, electron microscopy and immunostaining for LRP2, CUBN, and AMN. Follow-up data, including treatment(s), laboratory values, and outcomes, were available from 51 patients.

Results

SUBMITTER: Murphy JD 

PROVIDER: S-EPMC10851064 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature