β-Blocker Withdrawal and Functional Capacity Improvement in Patients With Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Importance

Increasing the patient's heart rate (HR) has emerged as a therapeutic option in patients with heart failure with preserved ejection fraction (HFpEF). However, the evidence is conflicting, and the profile of patients who benefit most from this strategy remains unclear.

Objective

To assess the association of β-blocker treatment withdrawal with changes in the percentage of predicted peak oxygen consumption (VO2) across indexed left ventricular diastolic (iLVEDV) and indexed left ventricular systolic volumes (iLVESV), and left ventricular ejection fraction (LVEF) in patients with HFpEF and chronotropic incompetence.

Design, setting, and participants

This post hoc analysis was conducted using data from the investigator-blinded multicenter, randomized, and crosso

SUBMITTER: Palau P 

PROVIDER: S-EPMC10851133 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature