Sex-Specific Pathways From Prenatal Maternal Inflammation to Adolescent Depressive Symptoms.

ABSTRACT:

Importance

Prenatal maternal inflammation has been associated with major depressive disorder in offspring in adulthood as well as with internalizing and externalizing symptoms in childhood; however, the association between prenatal inflammation and offspring depression in adolescence has yet to be examined.

Objective

To determine whether maternal levels of inflammatory biomarkers during pregnancy are associated with depressive symptomatology in adolescent-aged offspring and to examine how gestational timing, offspring sex, and childhood psychiatric symptoms impact these associations.

Design, setting, and participants

This was an observational study of a population-based birth cohort from the Child Health and Development Studies (CHDS), which recruited almost all mothe

SUBMITTER: Lipner E 

PROVIDER: S-EPMC10851141 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature