Age-specific breast and ovarian cancer risks associated with germline <i>BRCA1</i> or <i>BRCA2</i> pathogenic variants - an Asian study of 572 families.

ABSTRACT:

Background

Clinical management of Asian BRCA1 and BRCA2 pathogenic variants (PV) carriers remains challenging due to imprecise age-specific breast (BC) and ovarian cancer (OC) risks estimates. We aimed to refine these estimates using six multi-ethnic studies in Asia.

Methods

Data were collected on 271 BRCA1 and 301 BRCA2 families from Malaysia and Singapore, ascertained through population/hospital-based case-series (88%) and genetic clinics (12%). Age-specific cancer risks were estimated using a modified segregation analysis method, adjusted for ascertainment.

Findings

BC and OC relative risks (RRs) varied across age groups for both BRCA1 and BRCA2. The age-specific RR estimates were similar across ethnicities and country of r

SUBMITTER: Ho WK 

PROVIDER: S-EPMC10851205 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature