Alterations in cortical volume and complexity in Parkinson's disease with depression.

ABSTRACT:

Aims

The aim of this study is to investigate differences in gray matter volume and cortical complexity between Parkinson's disease with depression (PDD) patients and Parkinson's disease without depression (PDND) patients.

Methods

A total of 41 PDND patients, 36 PDD patients, and 38 healthy controls (HC) were recruited and analyzed by Voxel-based morphometry (VBM) and surface-based morphometry (SBM). Differences in gray matter volume and cortical complexity were compared using the one-way analysis of variance (ANOVA) and correlated with the Hamilton Depression Scale-17 (HAMD-17) scores.

Results

PDD patients exhibited significant cortical atrophy in various regions, including bilateral medial parietal-occipital-temporal lobes, right dorsolateral temporal lobes, bilatera

SUBMITTER: Yuan J 

PROVIDER: S-EPMC10851315 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature