Serum response factor promoting axonal regeneration by activating the Ras-Raf-Cofilin signaling pathway after the spinal cord injury.

ABSTRACT:

Introduction

Serum response factor (SRF) is important in muscle development, tissue repair, and neuronal regulation.

Objectives

This research aims to thoroughly examine the effects of SRF on spinal cord injury (SCI) and its ability to significantly impact the recovery and regeneration of neuronal axons.

Methods

The researchers created rat models of SCI and scratch injury to primary spinal cord neurons to observe the expression of relevant factors after neuronal injury.

Results

We found that the SRF, Ras, Raf, and cofilin levels increased after injury and gradually returned to normal levels. Afterward, researchers gave rats with SCI an SRF inhibitor (CCG1423) and studied the effects with nuclear magnetic resonance and transmission electron microscopy. The SRF in

SUBMITTER: Gao L 

PROVIDER: S-EPMC10851317 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature