Associations between impulsivity and fecal microbiota in individuals abstaining from methamphetamine.

ABSTRACT:

Introduction

Methamphetamine (MA) abuse is a major public problem, and impulsivity is both a prominent risk factor and a consequence of addiction. Hence, clarifying the biological mechanism of impulsivity may facilitate the understanding of addiction to MA. The microbiota-gut-brain axis was suggested to underlie a biological mechanism of impulsivity induced by MA.

Methods

We therefore recruited 62 MA addicts and 50 healthy controls (HCs) to investigate the alterations in impulsivity and fecal microbiota and the associations between them in the MA group. Thereafter, 25 MA abusers who abstained from MA for less than 3 months were followed up for 2 months to investigate the relationship between impulsivity and microbiota as abstinence became longer. 16S rRNA sequencing was cond

SUBMITTER: Liu W 

PROVIDER: S-EPMC10851322 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature