Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.

ABSTRACT: Vital to the treatment of influenza is the use of antivirals such as Oseltamivir (Tamiflu) and Zanamivir (Relenza); however, antiviral resistance is becoming an increasing problem for these therapeutics. The RNA-dependent RNA polymerase acidic N-terminal (PA_N) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target that was recently validated with the approval of Baloxavir Marboxil (BXM). Despite its clinical success, BXM has demonstrated susceptibility to resistance mutations, specifically the I38T, E23K, and A36 V mutants of PA_N. To better understand the effects of these mutations on BXM resistance and improve the design of more robust therapeutics, this study examines key differences in protein-inhibitor interactions with

SUBMITTER: Kohlbrand AJ 

PROVIDER: S-EPMC10851415 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature