Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study.

ABSTRACT:

Background

Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several neurodegenerative diseases. Nevertheless, the potential connection between serum lipids and LBD remains undetermined. In this study, Mendelian randomization (MR) analyses were carried out to assess the causal relationships of several serum lipid measures with the risk of developing LBD.

Methods

Genome-wide association study (GWAS) data for serum lipids and LBD in European descent individuals were acquired from publicly available genetic summary data. A series of filtering procedures were conducted to identify the genetic variant candidates that are related to serum lipids, including high-density lipopro

SUBMITTER: Liu P 

PROVIDER: S-EPMC10851540 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature