An improved method for estimating low LDL-C based on the enhanced Sampson-NIH equation.

ABSTRACT:

Background

The accurate measurement of Low-density lipoprotein cholesterol (LDL-C) is critical in the decision to utilize the new lipid-lowering therapies like PCSK9-inhibitors (PCSK9i) for high-risk cardiovascular disease patients that do not achieve sufficiently low LDL-C on statin therapy.

Objective

To improve the estimation of low LDL-C by developing a new equation that includes apolipoprotein B (apoB) as an independent variable, along with the standard lipid panel test results.

Methods

Using β-quantification (BQ) as the reference method, which was performed on a large dyslipidemic population (N = 24,406), the following enhanced Sampson-NIH equation (eS LDL-C) was developed by least-square regression analysis: [Formula: see text] RESULTS: The eS LDL-C equation was

SUBMITTER: Coverdell TC 

PROVIDER: S-EPMC10851542 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature