Gene expression analysis reveals diabetes-related gene signatures.

ABSTRACT:

Background

Diabetes is a spectrum of metabolic diseases affecting millions of people worldwide. The loss of pancreatic β-cell mass by either autoimmune destruction or apoptosis, in type 1-diabetes (T1D) and type 2-diabetes (T2D), respectively, represents a pathophysiological process leading to insulin deficiency. Therefore, therapeutic strategies focusing on restoring β-cell mass and β-cell insulin secretory capacity may impact disease management. This study took advantage of powerful integrative bioinformatic tools to scrutinize publicly available diabetes-associated gene expression data to unveil novel potential molecular targets associated with β-cell dysfunction.

Methods

A comprehensive literature search for human studies on gene expression alterations in the pancreas as

SUBMITTER: Farrim MI 

PROVIDER: S-EPMC10851551 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature