Collagen type IV alpha 1 chain (COL4A1) expression in the developing human lung.

ABSTRACT:

Background

Collagen type IV alpha 1 chain (COL4A1) in the basement membrane is an important component during lung development, as suggested from animal models where COL4A1 has been shown to regulate alveolarization and angiogenesis. Less is known about its role in human lung development. Our aim was to study COL4A1 expression in preterm infants with different lung maturational and clinical features.

Methods

COL4A1 expression in 115 lung samples from newborn infants (21-41 weeks' gestational age; 0-228 days' postnatal age [PNA]) was studied by immunohistochemistry combined with digital image analysis. Cluster analysis was performed to find subgroups according to immunohistologic and clinical data.

Results

Patients were automatically categorized into 4 Groups depending

SUBMITTER: Markasz L 

PROVIDER: S-EPMC10851591 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature