Preoperative predictors for non-resectability in perihilar cholangiocarcinoma.

ABSTRACT:

Introduction

Explorative laparotomy without subsequent curative-intent liver resection remains a major clinical problem in the treatment of perihilar cholangiocarcinoma (pCCA). Thus, we aimed to identify preoperative risk factors for non-resectability of pCCA patients.

Material and methods

Patients undergoing surgical exploration between 2010 and 2022 were eligible for the analysis. Separate binary logistic regressions analyses were used to determine risk factors for non-resectability after explorative laparotomy due to technical (tumor extent, vessel infiltration) and oncological (peritoneal carcinomatosis, distant nodal or liver metastases)/liver function reasons.

Results

This monocentric cohort comprised 318 patients with 209 (65.7%) being surgically resected and 1

SUBMITTER: Otto CC 

PROVIDER: S-EPMC10851609 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature