Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer.

ABSTRACT:

Background

Cancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers. CTA overexpression drives the metastasis and progression of lung cancer, and is associated with poor prognosis. To improve lung cancer diagnosis, prognostic prediction, and drug discovery, robust CTA identification and quantitation is needed. In this study, we examined and quantified the co-expression of CTAs in lung cancer to derive cancer testis antigen burden (CTAB), a novel biomarker of immunotherapy response.

Methods

Formalin fixed paraffin embedded (FFPE) tumor samples in discovery cohort (n = 5250) and immunotherapy and combination therapy treated non-small cell lung cancer (NSCLC) retrospective (n = 250) cohorts were t

SUBMITTER: Seager RJ 

PROVIDER: S-EPMC10851610 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature